Izilingo Zomtholampilo

Awekho ama-induration amasha abonwe eqenjini le-NIF uma kuqhathaniswa ne-IP.(P=0.0150) Inalithi ephukile ibonwe eqenjini le-IP, abukho ubungozi eqenjini le-NIF.Ukwehliswa kwesilinganiso esilungisiwe kusukela kusisekelo se-HbA1c 0.55% ngeviki le-16 eqenjini le-NFI kwakungeyona ngaphansi futhi kuphakeme ngokwezibalo uma kuqhathaniswa nalokho kuka-0.26% eqenjini le-IP.Ukuphathwa kwe-insulin nge-NIF kunganikeza iphrofayili yokuphepha engcono kunemijovo ye-IP, ngokunciphisa imihuzuko esikhunjeni, ukuqina, ubuhlungu kanye kungabikho bungozi bezinaliti eziphukile.

Isingeniso:

Ingxenye yeziguli ezinesifo sikashukela sohlobo 2 ezisebenzisa i-insulin isephansi kakhulu futhi imvamisa iqalwa sekudlule isikhathi.Kutholakale izici eziningi ezithinta ukubambezeleka kokusetshenziswa kwe-insulin, okuhlanganisa ukwesaba izinaliti, ukuphazamiseka kwengqondo ngesikhathi sokujova i-insulin kanye nokuphazamiseka komjovo we-insulin, konke okuyizizathu ezibalulekile zeziguli ezinqaba ukuqala ukwelashwa kwe-insulin.Ngaphezu kwalokho, inkinga yomjovo efana ne-induration ebangelwa ukusetshenziswa kabusha kwezinaliti zesikhathi eside nakho kungathinta ukusebenza kahle kokwelashwa kwe-insulin ezigulini esezivele ziyisebenzisile i-insulin.

Umjovo we-insulin ongenanalithi wenzelwe iziguli ezinesifo sikashukela ezesaba ukujova noma ezimanqikanqika ukuqalisa ukwelashwa kwe-insulin uma kukhonjiswe ngokucacile.Lolu cwaningo beluhlose ukuhlola ukwaneliseka kwesiguli kanye nokuhambisana nomjovo we-insulin engenanalithi uma uqhathanisa nemijovo yepeni evamile ye-insulin ezigulini ezine-T2DM elashwa amasonto ayi-16.

Izindlela:

Ingqikithi yeziguli ezingama-427 ezine-T2DM zabhaliswa ocwaningweni oluhlanganisa izikhungo eziningi, ezilindelekile, ezingahleliwe, ezinelebula evulekile, futhi zahlelwa ngokungahleliwe ngo-1:1 ukuze zithole i-basal insulin noma i-insulin exutshwe ngaphambili ngomjovo ongenanaliti noma ngemijovo yepeni ye-insulin evamile.

Umphumela:

Ezigulini ezingama-412 eziphothule ucwaningo, kusho ukuthi amaphuzu emibuzo ye-SF-36 anyuswe kakhulu kuwo womabili umjovo ongenazinaliti kanye namaqembu ajwayelekile epeni le-insulin, kungekho mehluko omkhulu phakathi kwamaqembu ngokuhambisana.Kodwa-ke, izihloko zeqembu lomjovo ongenazinaliti zibonise amaphuzu ekwaneliseka aphezulu kakhulu kunalawo aseqenjini lepeni le-insulin elivamile ngemva kwamasonto angu-16 okwelashwa.

Isifinyezo:

Awukho umehluko omkhulu phakathi kwepeni le-insulini namaqembu omjovo ongenazinaliti kulo mphumela we-SF-36.

Umjovo we-insulin ongenanaliti uholela ekwanelisekeni okuphezulu kwesiguli kanye nokuhambisana nokwelashwa okuthuthukisiwe.

Isiphetho:

Umjovo ongenanalithi wathuthukisa izinga lempilo yeziguli ze-T2DM futhi wathuthukisa kakhulu ukwaneliseka kwazo ngokwelashwa kwe-insulin uma kuqhathaniswa nemijovo yepeni ye-insulin evamile.